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Measurement of decrease in thickness of diaphragm in patients on artificial ventilation

Comparison of diaphragmatic atrophy in patients on ventilatory support with SIMV plus PS mode and ACMV mode: A prospective randomized controlled trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/11/010621
Enrollment
42
Registered
2017-11-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Critically ill patients admitted to the ICU requiring mechanical ventilatory support

Interventions

Intervention1: SIMV with PS: Mechanical ventilation using SIMV mode with pressure support Control Intervention1: ACMV: Mechanical ventilation using Assist-Control mode

Sponsors

Lakshminarayana Yaddanapudi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients requiring mechanical ventilation after admission to ICU

Exclusion criteria

Exclusion criteria: 1. Mechanical ventilation (invasive and noninvasive) before coming into ICU 2. Patients who are not started on enteral feeding within 24 hours of coming into ICU 3. Patients with known neuromuscular disorders and anatomical malformations of the thorax 4. Patients with neuroparalytic snake bite 5. Patients with organophosphorous compound poisoning 6. Usage of neuromuscular blockers during ventilation 7. Pregnancy

Design outcomes

Primary

MeasureTime frame
Decrease in diaphragmatic thickness measured by ultrasoundTimepoint: 1st day of ventilation 3rd day of ventilation (72 hours after the first measurement)

Secondary

MeasureTime frame
Duration of ventilationTimepoint: At the time of transfer from the ICU

Countries

India

Contacts

Public ContactLakshminarayana Yaddanapudi

PGIMER

trnishanthpgi@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026