Health Condition 1: G040- Acute disseminated encephalitis and encephalomyelitis (ADEM) Health Condition 2: G040- Acute disseminated encephalitis and encephalomyelitis (ADEM) Health Condition 3: null- children with acute disseminated encephalomyelitis
Conditions
Interventions
Intervention1: intravenous imunoglobulin(IVIG): intravenous immunoglobulin G (IVIG) at a dosage of 2 g/kg divided over 2 to 5 days
Control Intervention1: methylprednisolone: intravenous methylpredniso
Sponsors
Banaras Hindu University
Eligibility
Inclusion criteria
Inclusion criteria: All children admitted in emergency pediatric ward with â?? Clinical feature â?? 1.unilateral or bilateral pyramidal sign, 2.Acute hemiplegia, 3.ataxia, 4. cranial Nerve Palsy, 5.seizure, 6.vision loss due to optic neuritis, impairment of speech (slow, slurred or aphasia) 7.hemiparesis, 8.change in mental status (ranging from lethergy to coma) with 9.normal cerebrospinal fluid studies and 10.suggestive MR imaging i.e. increased signal intensity on T2 weighted image & fluid attenuated inversion recovery sequence (FLAIR) as large, globular, multiple and asymmetric lesion.
Exclusion criteria
Exclusion criteria: 1.Children with acute bacterial and tubercular meningitis 2.intracranial space occupying lesion, 3.underlying known autoimmune and connective tissue disorder will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neurological recoveryTimepoint: 7 days, 1 month, 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reaction of intravenous immunoglobulin treatmentTimepoint: three months;duration of stay in hospitalTimepoint: nil;residual neurological deficitTimepoint: three months | — |
Countries
India
Contacts
Public ContactRajniti Prasad
Banaras Hindu University
Outcome results
None listed