Health Condition 1: null- Patients of breast, cervix, head and neck and liver cancerundergoing diagnostic imaging (Mammography, CT scan, PET/CT, 4D CT) or therapeutic fractionated radiation
Conditions
Interventions
None listed
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1)Normal healthy volunteers exposed to background radiation: 50 2)Normal healthy volunteers exposed to diagnostic procedures:30 (healthy volunteers undergoing diagnostic mammogram, CT scans, PET/CT scans and x-rays as screening procedures) 3)Patients of breast, cervix, head and neck and liver cancer undergoing diagnostic imaging (Mammography, CT scan, PET/CT, 4D CT) or therapeutic fractionated radiation will be included in the study.
Exclusion criteria
Exclusion criteria: 1)No family history of cancer 2)Not diagnosed with any radiosensitive syndrome like Ataxia talengectesia/fanconiâ??s anemia. 3)Patients with diagnostic radiation should not have received any previous chemotherapy, hormone therapy, targeted therapy or radiation therapy and should not have undergone any radiographic imaging in the preceding 6 weeks. 4)Patients with therapeutic radiation should not be planned for any chemotherapy, hormone therapy or targeted therapy during the period of blood sampling for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA repair kinetics in terms of g H2AX expressionTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in expression of genes associated with DNA repair responseTimepoint: 3 years;Changes in pro inflammatory and antiinflammatory cytokine profile.Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactDr Rajendra A Badwe
Tata Memorial Hospital
Outcome results
None listed