Health Condition 1: null- Glaucoma
Conditions
Interventions
Intervention1: Valproic acid: Patients in intervention group will receive oral valproic acid 500mg OD for 3months (along with standard antiglaucoma medications, if needed)
Control Intervention1: Cont
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. End stage glaucoma at least in one eye having a visual acuity of at least 6/36. (visual feild less than 10deg radius and mean deviation worse than 24dB) 2. IOP < 18 mm Hg on 2 consecutive visits (well controlled intraocular pressure)
Exclusion criteria
Exclusion criteria: 1. Patients with any other disease that might have contributed to visual field loss at the time of initial visual field test.(These diseases include other optic neuropathies, strokes, brain tumours, retinal vein or artery occlusion, macular disease including age-related macular degeneration, central retinal detachment and proliferative diabetic retinopathy.) 2. Patients already on oral valproic Acid for any other systemic illness. 3. Patients allergic to valproic acid, peanut oil. 4. Patients with deranged liver function test, hepatitis, alcoholic liver diseases. 5. Female patients in childbearing age , who did not undergo family planning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Acuity, Visual Field, Multifocal Electroretinigram.Timepoint: baseline, 3 months, 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Macular thicknessTimepoint: baseline,3 Months. | — |
Countries
India
Contacts
Public ContactDr Karthikeyan Mahalingam
AIIMS
Outcome results
None listed