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To compare two drugs, dexamethasone and granisetron in their ability to prevent vomiting after surgery in women

Double blinded randomized controlled study to compare the efficacy of dexamethasone with granisetron in prevention of postoperative nausea and vomiting in female patients undergoing laparoscopic surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/11/010507
Enrollment
50
Registered
2017-11-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Postoperative nausea and vomiting in female patients undergoing elective laparoscopic surgery

Interventions

Intervention1: Dexamethasone: Dexamethasone 8 mg administered intravenously at the time of induction of anesthesia Control Intervention1: Granisetron: Granisetron 3 mg administered intravenously at th

Sponsors

Sri Ramachandra Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II Female patients undergoing elective laparoscopic procedures Non pregnant

Exclusion criteria

Exclusion criteria: Emergency surgery ASA III and above Patients with preoperative vomiting BMI greater than 30 History of steroid use Patients with contraindication to study drugs Pregnancy and lactation

Design outcomes

Primary

MeasureTime frame
PONV intensity scoreTimepoint: 6h, 12h, 18h, 24h, 72h after surgery—

Secondary

MeasureTime frame
Time of first rescue antiemetic administration, total postoperative metoclopramide consumptionTimepoint: 24h, 72h after surgery—

Countries

India

Contacts

Public ContactAruna Parameswari

Sri Ramachandra Medical College and Research Institute

reetharun@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026