Health Condition 1: null- American Society of Anaesthesiology, GRADE-I, Healthy patients, undergoing surgery.
Conditions
Interventions
Intervention1: Group 1: group I (Ivabradine group) Intervention with oral ivabradine.: Group 1 The patients will be given tablet ivabradine 7.5mg orally 2 hours before surgery. Patients will undergo s
Sponsors
Dr Anwesha Banerjee
Prof Sanghamitra Mishra
Eligibility
Inclusion criteria
Inclusion criteria: Patient belonging to ASA, Grade-I status, posted for elective non-cardiac abdominal laprscopic surgeries of 2-4 hour estimated duration.
Exclusion criteria
Exclusion criteria: 1) Patients with history of any medication or substance abuse 2) Age 50 year 3) Weight 70 kg 4) Height 170cm 5) Baseline heart rate =90 bpm 6) Baseline Blood Pressure =140/85/105 mm Hg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare tachycardia and hypertension incidence in both groups.Timepoint: i) Just before laryngoscopy. ii) Immediately after intubation. iii) Every minute after intubation till 5 minutes. iv) At time of surgical incision. v) Every minute till 5 minutes of incision. vi) At time of recovery from anaesthesia. vii) Every one minute till 5 minutes of extubation. viii) Ten minutes after extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| A) To find out incidence of following in both groups Bradycardia (â?¤60 beats/minutes) Absolute Bradycardia (â?¤60 beats/minutes) Tachycardia (â?¥90 beats/minutes) Hypotension (â?¤90/50/65 mmHg) Hypertension (â?¥140/85/105 mmHg) Timepoint: Every ten minutes intraoperatively starting from 15 minutes before intubation till 10 minutes after extubation.;B) To find out any other adverse effect of the drug ivabradine.Timepoint: From one hour after taking drug till 24 hours | — |
Countries
India
Contacts
Public ContactDr Sanghamitra Mishra
Institute of Medical Science and SUM Hospital
Outcome results
None listed