Health Condition 1: null- Acute asthma
Conditions
Interventions
Intervention1: Non-invasive ventilation (CPAP): NIV (CPAP) group: CPAP device with face mask will be fitted to the childâ??s face, with settings: Starting pressure 8 cm H2O, increased to 10 cm H2O if
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Children >24 months old, presenting to the Pediatric Emergency with acute asthma. Acute asthma will be diagnosed on the basis of (i) respiratory rate greater than WHOâ??s age-dependent WHO criteria; (ii) history of similar previous episodes or physician diagnosed asthma; and (iii) wheezing heard on auscultation.
Exclusion criteria
Exclusion criteria: 1. Clinical suspicion of bacterial pneumonia on the basis of: focal crackles or bronchial breathing, and/or chest x-ray findings suggesting pneumonia (consolidation, major infiltrates, pleural effusion). 2. Impending respiratory failure at presentation requiring direct PICU admission 3. Any contraindication to BiPAP use including altered mental status, recent bowel surgery, intractable vomiting, inability to protect airway 4. Current tracheostomy, home ventilation (IPPV or NIPPV) or home oxygen requirement 5. Prior receipt of oral steroid at the time of presentation 6. History of congenital heart disease or chronic respiratory disease (including bronchopulmonary dysplasia, cystic fibrosis, pulmonary hypertension) 7. Craniofacial abnormality 8. Pneumothorax.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of time to reach a PRAM score of less than or equal to 3Timepoint: Length of time after admission | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of time to achieve hospital discharge criteria. 2. Length of time for omission of oxygen 3. Requirement of supplemental bronchodilator (median number of intravenous infusion hours, total salbutamol doses per patient per admission, median doses of salbutamol per day) 4. Requirement of intubation and invasive ventilation 5. Treatment-related adverse events 6. Readmission within 48 hours of discharge 7. In children who perform PFT, time to reach FEV1 80% predicted Timepoint: As defined in each item above. | — |
Countries
India
Contacts
Public ContactJoseph L Mathew
PGIMER Chandigarh
Outcome results
None listed