To compare the effectiveness of two drugs in prevention of fall in blood pressure after spinal anaesthesia.

A comparative study between mephentermine and ondansetron for prevention of postspinal hypotension.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/11/010450

Enrollment

130

Registered

2017-11-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I AND II PATIENTS

Interventions

Intervention1: Mephentermine injection, intravenous.: Mephentermine injection 6mg diluted upto 5ml with saline. Control Intervention1: Ondansetron injection, intravenous.: Ondansetron injection 4mg di

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I & II, Patients able to comprehend and willing to participate.Patients in whom spinal anaesthesia is indicated.

Exclusion criteria

Exclusion criteria: PATIIENTS REFUSAL, SENSITIVITY TO STUDY DRUGS, PRESENCE OF INFECTION ON THE SPINAL INJECTION SITE.

Design outcomes

Primary

Measure	Time frame
Incidence and severity of hypotension after prophylactic administration of study drug.Timepoint: 0, 5, 10, 15, 20, 25, 30 MINUTES	—

Secondary

Measure	Time frame
Any adverse effects.Timepoint: 0, 5, 10, 15, 20, 25, 30 Minutes.	—

Countries

India

Contacts

Public ContactKriti

pkdubey@hotmail.com09473191821

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026