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Comparison between two ventilatory modes in reducing the days of mechanical ventilation and also assosciated complications.

Volume-Targeted Ventilation versus Pressureâ??Limited Ventilation in Respiratory Distress Syndrome in Prematurely Born Infants- Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/11/010439
Enrollment
130
Registered
2017-11-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Prematurely born newborns with Respiratory distress syndrome

Interventions

Intervention1: Volume targeted ventilation as the interventional group: comparison of two ventilatory modes in prematurely born newborns with respiratory distree syndrome Intervention2: pressure limit

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Neonates with congenital cyanotic heart diseases. 2 Neonates with major congenital malformations. 3 Neonates with air leak syndromes. 4 Neonates requiring High Frequency Oscillatory Ventilation (HFOV)

Exclusion criteria

Exclusion criteria: 1.Neonates with congenital cyanotic heart diseases. 2.Neonates with major congenital malformations. 3.Neonates with air leak syndromes. 4.Neonates requiring High Frequency Oscillatory Ventilation (HFOV)

Design outcomes

Primary

MeasureTime frame
Primary outcome is to compare the time required to reach the weaning criteria assessed by volume targeted ventilation to pressure limited ventilation in prematurely born infants.Timepoint: At the time of extubation—

Secondary

MeasureTime frame
1 Rate of failure 2 Oxygenation Index at 6th hourly 3 FiO2 to SpO2 ratio 4 PaO2 to FiO2 ratio 5 Episodes of hypocarbia at 2nd hourly 6 Duration of mechanical ventilation 7 Oxygen radicals 8 Complications such as 9 Broncho pulmonary dysplasia(BPD) 10 Periventricular leukomalacia(PVL) 11 Air leak syndrome 12 Intraventricular Hemorrhage (IVH) 13 Retinopathy of Prematurity (ROP) 14 Mortality Timepoint: at the time of extubation and at the time of discharge—

Countries

India

Contacts

Public ContactGokul krishna G

kasturba medical college

leslielewis1@gmail.com9108598185

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026