Health Condition 1: null- Children diagnosed with Acute on Chronic Liver Failure, presenting with or without Hepatic Encephalopathy Grade 1 or Grade 2
Conditions
Interventions
Intervention1: No GCSF: Comparison of GCSF and no GCSF in study group and control group of children with Acute on chronic Liver Failure
Control Intervention1: Granulocyte colony stimulating factor (G-
Sponsors
Departmental Fund
Eligibility
Inclusion criteria
Inclusion criteria: 1. Jaundice and coagulopathy, complicated within 4 weeks by ascites and/or encephalopathy. 2. Evidence of chronic liver disease on history/examination/investigations 3. Jaundice [serum bilirubin >5 mg/dl] 4. Coagulopathy (INR >1.5/prothrombin activity 5. Complicated within 4 weeks by ascites and/or encephalopathy (as determined by clinical examination).
Exclusion criteria
Exclusion criteria: 1. Previous episodes of Decompensated cirrhosis 2. Tropical infection related hepatopathy with high grade fever 3. Age of 4. Portal vein thrombosis 5. Severe sepsis/ Multi-organ failure at presentation 6. Grade 3 or 4 hepatic encephalopathy 7. HIV seropositive 8. Any previous known hypersensitivity to G-CSF 9. Any significant comorbidity 10. Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the outcome of children with ACLF receiving GCSF with those not receiving GCSF at Day 30 and Day 60Timepoint: To compare the outcome of children with ACLF receiving GCSF with those not receiving GCSF at Day 30 and Day 60 | — |
Secondary
| Measure | Time frame |
|---|---|
| CD 34 cell count Clinical and Biochemical ProfileTimepoint: 60 days | — |
Countries
India
Contacts
Public ContactShruti Sharma
PGIMER
Outcome results
None listed