Health Condition 1: null- Post Menopausal Women with Impaired Cognitive Function
Conditions
Interventions
Intervention1: Methylcobalamin (Vitamin B12): 500 mcg once daily for 12 Weeks (Oral)
Control Intervention1: Ascorbic Acid: Vitamin C
Control Intervention2: Ascorbic Acid (Vitamin C): 500 mg once daily
Sponsors
SRM University
Eligibility
Inclusion criteria
Inclusion criteria: 1. MMSE Score 21-24 2. Menopausal women (taken as complete cessation of menstruation for at least 1 year/12 cycles) who had attained menopause for a period extending over 4 â?? 10 years at the time of inclusion into the study.
Exclusion criteria
Exclusion criteria: 1. MMSE Score 25-30 2. History of recent or current Estrogen or hormonal replacement therapy 3. Known hypertensive, diabetic, renal disease, endocrine disorders, overt nutritional deficiency states, anemia, liver disease or those having history of psychiatric illness. 4. History of Women having estrogen secreting ovarian tumors, for e.g., granulosa and theca cell tumors, tumors of the adrenal gland. 5. Known history of neurological disorders including CVA, space occupying lesions, epilepsy and developmental anomalies. 6. Women, who are physically unable to hear, read or understand written or explained instructions properly, or may have a motor deficit that affects writing and drawing skills. 7. Women, who are already in any of the antioxidant or dietary supplement therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vitamin B12 and Vitamin C Effects on Cognitive Function will be studiedTimepoint: Baseline, 45 days, 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Relation between estrogen and cognitive function will be studiedTimepoint: Baseline, 45 days, 90 days | — |
Countries
India
Contacts
Public ContactDr Lakshmi KS
SRM University
Outcome results
None listed