Health Condition 1: null- Non Affective Psychosis
Conditions
Interventions
Intervention1: Drug Risperidone and Olanzapine: Risperidone 2-8 mg/day for 8 week.
Olanzapine 10-30mg/day for 6 weeks.
Control Intervention1: Not Applicable: Not Applicable
Sponsors
Goverment Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patient should meet the following psychopathology severity criteria at the time of inclusion into the study 1.total score extracted from Positive and Negative Syndrome Scale should be atleast 45 2. A score of atleast 4 [moderate] on at least 2 of following BPRS items: conceptual disorganization, suspiciousness, hallucinatory behavior and unusual thought content 3.Patient who are either drug naïve or who had relapsed in preceding 2 weeks requiring change in medications.
Exclusion criteria
Exclusion criteria: 1.Patient with history of inadequate response to risperidone or olanzapine in the past. 2.Patient with history of allergic reaction to risperidone or olanzpine 3.History of use of risperidone or olanzapine with in past 30 days before the study enrolment. 4.Acute, serious or unstable co-morbid medical condition 5.Schizo-affective disorder 6.Active substance dependence except nicotine and caffeine 7.Pregnant and lactating women 8.Treatment resistant schizophrenia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Identify the early responder and non responder 2.the response rate amongst the early non-responders after either continuing on the same antipsychotic or being switched over to another atypical antipsychoticTimepoint: 1t week,2nd week,4th week,6th week,8th week. | — |
Secondary
| Measure | Time frame |
|---|---|
| 20% Reduction in the illness severity on PANSS.Timepoint: 2nd week | — |
Countries
India
Contacts
Public ContactBS Chavan
Goverment Medical College and Hospital
Outcome results
None listed