Health Condition 1: null- Cutaneous lichen planus
Conditions
Interventions
Intervention1: Oral prednisolone: 0.15 mg/kg/day to 0.5 mg/kg/day daily for 8 weeks
Intervention2: Oral isotretinoin: 10 mg/day to 20 mg/day daily for 8 weeks
Control Intervention1: Cutaneous lichen p
Sponsors
Krishna Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: A.Must give written consent before any treatment commenced. B.Must be diagnosed to be suffering from cutaneous lichen planus either by clinical examination or histopathology if required. C.Must have generalised lichen planus involving minimum 20% body surface area or cases of palmoplantar lichen planus D.Must stop any other modality of treatment, two months prior to the inclusion in study. E.Must be able and willing, in the view of investigator, to comply all study procedure.
Exclusion criteria
Exclusion criteria: A. Patient having only oral lichen planus, genital lichen planus, nail lichen planus, follicular lichen planus, actinic lichen planus, lichen planus pigmentosus, lichen planus pemphigoides, B. Patient with hypersensitivity to drug or patient intolerant to the study medication. C. Pregnant and lactating patient. D. Patient with unrealistic expectations. E. Not willing for regular follow up. F. Patient with clinically significant cardiovascular, haematological, pancreatic, metabolic neurological or any other laboratory anomaly, which in the judgement of investigator, would interfere in participation in study or proper evaluation. G. Patient on any other systemic drugs therapy which in the judgement of investigator may interfere with interpretation of results. H. Patient having history of tuberculosis or chest X-ray showing evidence of any infective pathology. I. Immunocompromised patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.) Body surface area 2.) Lichen planus severity indexTimepoint: 56 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Physician global assessmentTimepoint: 56 days;Visual analogue scaleTimepoint: 56 days | — |
Countries
India
Contacts
Public ContactHarsimran Kaur
Krishna Institute of Medical Sciences
Outcome results
None listed