Health Condition 1: null- MAJOR DEPRESSIVE DISORDER
Conditions
Interventions
Intervention1: Vilazodone: Tab Vilazodone 20 mg daily for 12 weeks
Control Intervention1: Escitalopram: Tab Escitalopram 20 mg daily for 12 weeks
Control Intervention2: Amitriptyline: Tab Amitriptylin
Sponsors
Dr Renuka Kadam
Eligibility
Inclusion criteria
Inclusion criteria: i)Newly diagnosed patients of major depressive disorder (as per Diagnostic and Statistical Manual of Mental Disorder, edition V) ii)Hamilton Depression Rating Score(HAMD-17) >= 22 iii)Aged between 18-60 years iv)Either gender
Exclusion criteria
Exclusion criteria: i)Pregnant and lactating women ii)Women of reproductive age group who are not practicing a reliable method of contraception iii)Patients of severe depression who may not respond to pharmacotherapy alone in the opinion of the psychiatrist iv)Treatment with electroconvulsive therapy within 3 months v)Any other psychiatric disorders except generalized anxiety disorder vi)Abnormal renal/hepatic function vii)Patients requiring other psychotropic medications, central nervous system active drugs viii)Patients on drug therapy for any other systemic disorder ix)Patients who have taken an investigational drug or participated in an investigational drug trial within the past 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in score on the hamilton depression rating scale from baseline to week 12Timepoint: Baseline 2 weeks 4 weeks 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Change in score on the montgomery asberg depression rating scale (madrs) from baseline to week 12 2)Change in score on the hamilton anxiety rating scale (ham-a) from baseline to week 12 3)To compare tolerability of vilazodone with escitalopram & amitriptyline, in patients of major depressive disorder Timepoint: Baseline 2 weeks 4 weeks 12 weeks | — |
Countries
India
Contacts
Public ContactDr Renuka Kadam
Government Medical College and Hospital Nagpur
Outcome results
None listed