This Study Evaluates the Effect of Scaling and Root planing on GCF and Serum Leptin Levels in Periodontally Healthy, Chronic Periodontitis and Chronic Periodontitis with Type 2 Diabetes Mellitus Patients.

Effect of Non-Surgical Periodontal Therapy on GCF and Serum Leptin Levels in Periodontally Healthy, Chronic Periodontitis and Chronic Periodontitis with Type 2 Diabetes Mellitus Patients.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/10/010259

Enrollment

Registered

2017-10-31

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Periodontally healthy patients Chronic periodontitis Diabetes Mellitus with Chronic periodontitis

Interventions

Intervention1: Non surgical periodontal therapy: In this study non surgical periodontal therapy will be provided to periodontally healthy, chronic periodontitis and chronic periodontitis with type II

Eligibility

Inclusion criteria

Inclusion criteria: Group 1 Patients with clinically healthy periodontium GI-0, PD less than or equal to 3mm and CAL- 0 with no evidence of bone loss, HbA1c levels less than 6.5 % and RBS levels less than 160 mg/dl Group II Generalized moderate to severe chronic periodontitis patients with GI greater than or equal to 1, greater than 30% of sites having PPD of greater than or equal to 5mm, positive BOP and CAL of greater than or equal to 5mm with radiographic evidence of bone loss, HbA1c levels less than 6.5 % and RBS levels less than 160 mg/dl Group III Generalized moderate to severe chronic periodontitis with Type 2 DM patients with GI score greater than 1, greater than 30% of sites having PPD of greater than or equal to 5mm, positive BOP and CAL of greater than or equal to 5mm with radiographic evidence of bone loss, HbA1c levels between 6.5- 8 % and RBS levels greater than 160 mg/dl

Exclusion criteria

Exclusion criteria: Medical disorders such as cardiovascular or renal disease Malignancies, multiple sclerosis and Tobacco chewers and smokers Pregnant, post-menopausal and lactating females No history of antibiotic intake within 6 weeks No history of any periodontal therapy within 6 months

Design outcomes

Primary

Measure	Time frame
Improvement in periodontal status that is reduction in probing pocket depth and gain in clinical attachment level in chronic periodontitis and chronic periodontitis with Type2 diabetes mellitus patientsTimepoint: 3 and 6 months	—

Secondary

Measure	Time frame
Improvement in serum and GCF leptin levels and RBS and HbA1c levels in chronic periodontitis and chronic periodontitis with Type2 diabetes mellitus patientsTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Abhay P Kolte

VSPM Dental College and Research Centre

drabhaypkolte@gmail.com9011071467

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026