â??various causes of hyponatremia and its relation to seizures and outcome in patients with acute febrile encephalopathy in neurology intensive care unit (NICU)â??.

â??Etiology of hyponatremia, its relation to seizures and outcome in acute febrile encephalopathy â?? A prospective study in neurology intensive care unit (NICU) patientsâ??.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/10/010255

Enrollment

Registered

2017-10-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients diagnosed as acute encephalitic syndrome. no comorbidities like uncontrol hypertension, liver failure renal failure, pregnancy, lactation

Interventions

Intervention1: fludrocortisone: Patients will receive fludrocortisone tablet (0.1 â?? 0.4 mg once daily)along with intravenous fluids (preferably normal saline) and oral salt supplementation (5 gm/ da

Eligibility

Inclusion criteria

Inclusion criteria: All patients with fever and altered sensorium within 10 days of their illness.

Exclusion criteria

Exclusion criteria: children <15years, pregnant and lactating women, malaria, septic, fungal and carcinomatous meningitis, head injury, stroke, tumors, malignancy, chronic renal failure, hepatic failure, Heart failure, Other secondary causes of hyponatremia (drugs, diuretics).

Design outcomes

Primary

Measure	Time frame
No of days required to correct sodium to 135 meq/L.Timepoint: 1 month	—

Secondary

Measure	Time frame
Dose of fludrocortisone required to reach primary outcome. No. of patients developing intolerance to fludrocortisone (hypertension, hypokalemia). Seizures due to hyponatremia. Disability at discharge, 3 and 6 months based on modified Barthel index and m RS score. Mortality at 28 days, 3 months and 6 months. Residual deficits in terms of seizures, cognitive, cranial nerve and motor deficits at the end of 6 months Timepoint: 1 month	—

Measure

Time frame

Dose of fludrocortisone required to reach primary outcome. No. of patients developing intolerance to fludrocortisone (hypertension, hypokalemia). Seizures due to hyponatremia. Disability at discharge, 3 and 6 months based on modified Barthel index and m RS score. Mortality at 28 days, 3 months and 6 months. Residual deficits in terms of seizures, cognitive, cranial nerve and motor deficits at the end of 6 months Timepoint: 1 month

—

Countries

India

Contacts

Public ContactDr U K Misra

Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)

drukmisra@rediffmail.com0522-2494167

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 23, 2026