Health Condition 1: null- Critically ill Mechanically ventilated Hypoalbuminemic Children with Fluid Overload
Conditions
Interventions
Intervention1: Albumin with furosemide: 20% albumin 5ml/kg iv infusion over 6hours with furosemide 0.05-0.2 mg/kg/hr iv infusion for 48hours
Control Intervention1: Normal saline with furosemide: norma
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: PICU stay > 48 hours Age 2 month to 12 years Mechanically ventilated Presence of fluid overload Decision by the treatment physician to achieve diuresis Hypoalbuminemia (serum albumin
Exclusion criteria
Exclusion criteria: Hemodynamic instability at the time of recruitment or during preceding 12 hours Children with severe acute malnutrition, cardiac disease, renal failure, liver failure, nephrotic syndrome or protein losing enteropathy Receipt of albumin transfusion in preceding 48 hours Receipt of furosemide in the preceding 12 hours History of adverse reaction to prior albumin transfusion Hemoglobin Serum Na+ > 155mEq/l and cannot be corrected prior to enrollment Serum K+
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator free daysTimepoint: ventilator free days | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause 28-day mortality Length of PICU stay Length of hospital stay among survivors Incidence of new onset/ progression of MODS Duration of furosemide infusion Need for dialysis at 28 days Number of adverse events related to study intervention Timepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr V Mounika Reddy
PGIMER, Chandigarh
Outcome results
None listed