A comparative clinical and microbiological trial to study the effects of two drugs, neem gel and chlorhexidine gel on dental plaque and gingival inflammation.

A comparative clinical and microbiological evaluation of effect of Neem gel and Chlorhexidine gel on dental plaque and gingivitis in 20-30 years old adults: a randomized controlled double blind clinical trial.

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/10/010243

Enrollment

Registered

2017-10-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 2.5% neem gel: 20 grams of carbopol 934P was added in 1000 ml of water and soaked for 24 hours to prepare the base gel. To this base gel 2.5% neem extract was added along with 0.06% pep

Eligibility

Inclusion criteria

Inclusion criteria: 1. Study participants with similar a. socioeconomic status (based on modified Kuppuswamyâ??s socio-economic status scale) b. oral hygiene methods 2. Subjects willing to participate in the study and with written informed consent. 3. Study participants having fair plaque score and moderate gingivitis assessed by Plaque Index [Loe H (1967)]53 and Gingival Index [Loe H and Silness J (1963)]54 respectively. 4. No loss of attachment 5. At least 20 natural teeth present 6. Ability and willingness of study participants to follow the study procedures and successfully complete the study.

Exclusion criteria

Exclusion criteria: 1. Overhanging restorations 2. Antibiotic therapy in last 3 months prior to commencement of the study. 3. Using any dentifrice / mouthwash having anti-inflammatory action. 4. Probing depth 3 mm 5. Presence of calculus 6. Presence of grossly decayed teeth 7. Study participants with any systemic disorders that require the use of medications with side effects known to affect oral health. 8. History of allergy to any component of medicament or oral care products. 9. Advanced periodontal disease (purulent exudates, tooth mobility, and/or extensive alveolar bone loss) 10. Study participants who are physically or mentally handicap. 11. Pregnant and lactating females. 12. Study participants using prosthodontic appliances, crowns or restorations on facial and lingual surfaces of teeth. 13. Habit of consuming any kind of tobacco product.

Design outcomes

Primary

Measure	Time frame
Plaque and gingival scores by using: 1. Plaque Index given by Loe H (1967 2. Gingival Index given by Loe H and Silness J (1963) and 3. total colony counts of S. mutans and Lactobacilli from dental plaque samplesTimepoint: Plaque and gingival scores at 0th day 30th day and 90th dayby using: 1. Plaque Index given by Loe H (1967 2. Gingival Index given by Loe H and Silness J (1963) and 3. total colony counts of S. mutans and Lactobacilli from dental plaque samples	—

Measure

Time frame

Plaque and gingival scores by using: 1. Plaque Index given by Loe H (1967 2. Gingival Index given by Loe H and Silness J (1963) and 3. total colony counts of S. mutans and Lactobacilli from dental plaque samplesTimepoint: Plaque and gingival scores at 0th day 30th day and 90th dayby using: 1. Plaque Index given by Loe H (1967 2. Gingival Index given by Loe H and Silness J (1963) and 3. total colony counts of S. mutans and Lactobacilli from dental plaque samples

—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr Gargi NImbulkar

Sinhgad Dental College and Hospital, Pune

bravosquad@rediffmail.com9822418316

Outcome results