Comparative study of palonosetron and ondansetron for prevention of postoperative nausea and vomiting in patients undergoing lower abdominal surgery under regional anaesthesia

Comparative study of pre operative intravenous palonosetron and ondansetron for prevention of postoperative nausea and vomiting in patients undergoing lower abdominal surgery under regional anaesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/10/010215

Enrollment

100

Registered

2017-10-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I AND ASA 2

Interventions

Intervention1: Palonosetron Hydrochloride injection: Approved for prevention and treatment of nausea and vomiting Control Intervention1: Ondansetron Hydrochloride injection: approved for clinical use

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and ASA 2 Patient under going lower abdominal surgery under regional anaesthesia between 20 â?? 60 years of age

Exclusion criteria

Exclusion criteria: 1.Patients with difficulty in communicating, 2.Those prone to nausea, vomiting or motion sickness, 3.Patients previously on Opioid analgesic ,anti-emetics within 24 hours before anaesthesia, requiring continuous gastric suction for 24 hours in postoperative period, 4.Patient requiring use of opioid analgesics during intraoperative and post operative period will be excluded from study 5.Patients having Mallampatti grade-III or above were excluded from study 6.Patients with history of migrane 7.Pregnant & lactating patients

Design outcomes

Primary

Measure	Time frame
Nausea and Vomiting upto 24 hoursTimepoint: 24 hours	—

Secondary

Measure	Time frame
Nausea an Vomiting at 48 hourTimepoint: 48 hour	—

Countries

India

Contacts

Public ContactRaman Kesharwani

Peoples college of medical sciences,bhanpur bhopal

drmahimabatra@gmail.com9752075418

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026