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Changes seen in salivary flow and biohemical parameters in Patients with Head and Neck Cancer who recieves radiotherapy

Effects of Radiotherapy on Salivary- Secretion and Biochemical Parameters in Patients with Head and Neck Cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2017/10/010212
Enrollment
100
Registered
2017-10-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Normal

Interventions

None listed

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Histologically confirmed head & neck cancer patients above 18 years coming to ENT OPD who require radiotherapy (IMRT or Conventional Radiotherapy)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
The majority of patients in study population were of age group 50 to 70 years of age and there was a male preponderance in the study population. Salivary flow rate and pH showed a gradual decrease as age advances whereas amylase activity showed a non-significant increase. There was no sex predilection associated with baseline SFR, pH and amylase activity. Timepoint: Two years—

Secondary

MeasureTime frame
It was observed that there was a significant decrease in salivary flow rate (P less than 0.001), pH (P less than 0.001) and amylase (P less than 0.001) following 6 weeks of conventional radiotherapy. A non-significant change in SFR (P less than 0.078) and significant reduction in pH (P less than 0.03) and amylase (P equal to 0.001) was observed following 6 weeks of IMRT. Timepoint: Two years—

Countries

India

Contacts

Public ContactThomas John

JIPMER

sunil_58@rediffmail.com9442527018

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026