Health Condition 1: null- Patients with Lumbar PIVD, Lumbar vertebral fracture,lumbar spinal tumours.
Conditions
Interventions
Intervention1: Clonidine: Ropivacaine and clonidine administered via epidural route.
Intervention2: Epidural analgesia using catheter technique.: Epidural catheter is placed in the epidural space unde
Sponsors
IPGMER Hospital Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: 1.ASA physical status I/II 2.Age between 20yrs to 65 yrs. 3.Undergoing elective lumbar spine surgery a)laminectomy ± discectomy. b)Fracture fixation and instrumentation.
Exclusion criteria
Exclusion criteria: Patient refusal. 1.Known allergy to study drugs 2.Coagulopathies and platelet count 3.Significant systemic diseases. 4.Pre operative motor weakness and new onset post operative motor weakness. 5.Iatrogenic dural injury/tear
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dexmedetomidine as an adjuvant, was associated with better analgesic parameters as compared to clonidine. Timepoint: VAS scores were checked every 5 mins for the first 30 mins and then every 30 mins for the next 8 hours. 1. Onset of analgesia (VAS less than 4). 2.Time taken to reach peak level of analgesia (VAS equals to 0). 3.Duration of analgeisa (VAS more than 4). | — |
Secondary
| Measure | Time frame |
|---|---|
| Dexmedetomidine has better haemodynamic profile as compared with clonidine, when administered via epidural route.Timepoint: Heart rate, SBP,DBP,MAP were recorded every 30 mins for 8 hours.;Motor block ( Bromage scale) for lower limbs.Timepoint: Every hour for 8 hours.;Nausea and vomitingTimepoint: Throughout the study duration.;Respiratory rateTimepoint: Every hour.;Sedation ( Ramsay Sedation Score).Timepoint: Every hour. | — |
Countries
India
Contacts
Public ContactDr Amartya Das
IPGMER Kolkata
Outcome results
None listed