Comparative evaluation of topical Amphotericin B 0.1% versus topical Natamycin 5% in treatment of fungal corneal ulcer

Comparative evaluation of polyene antifungals(topical Amphotericin B 0.1% versus topicalL Natamycin 5%) in treatment of fungal corneal ulcer

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/10/010019

Enrollment

Registered

2017-10-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer Health Condition 2: null- Diagnosed case of moderate size fungal corneal ulcer

Interventions

Intervention1: Topical Liposomal Amphotericin B 0.1%: Topical Liposomal Amphotericin B 0.1% 2hrly till the ulcer start healing then 4 times per day Duration-3month Control Intervention1: Topical Nata

Eligibility

Inclusion criteria

Inclusion criteria: 1 KOH smear positive for fungal keratitis 2 Moderate ulcer size 3 Patients willing to give informed consent 4 Patients willing to follow up

Exclusion criteria

Exclusion criteria: Impending perforation,corneal perforation Bilateral ulcer Allergic to study medication No light perception in affected eye Pregnant or lactating females

Design outcomes

Primary

Measure	Time frame
1.Time to resolution of epithelial defect 2.Time to resolution of hypppyonTimepoint: 1.Time to resolution of epithelial defect 2.Time toresolution of hypopyon	—

Secondary

Measure	Time frame
Anatomical outcomes .Corneal opacity at the end of 3 months after enrollment .Corneal vascularisation at the end of 3 month after enrollment Functional outcomes .Best corrected visual acuity at the end of 3 month after enrollmentTimepoint: 3 Months	—

Countries

India

Contacts

Public ContactDr Kumar Parmanand

AIIMS

radhika_tan@yahoo.com01126593145

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026