Health Condition 1: null- children aged (corrected age) 1 month to 12 years admitted in PICU, will be included in the study within 24 hours of admission to PICU with stable hemodynamic parameters
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
The Director
Eligibility
Inclusion criteria
Inclusion criteria: All children aged (corrected age) 1 month to 12 years admitted in PICU, will be included in the study within 24 hours of admission to PICU with stable hemodynamic parameters (i.e Achieved immediate resuscitation goals (as directed by the treating physician) including fluid resuscitation AND/OR vasoactive therapy to achieve capillary refill of 5th percentile mean arterial blood pressure (MABP) for age, sex and length/height, normal pulses volume with no differential between peripheral and central pulses and urine output more than 1ml/kg/hour for at least 6 hours. Central venous pressure >=8 cmH2O (if measured), central venous oxygen saturation >=70% (if measured) AND/OR cardiac index between 3.3 and 6.0 L/min/m2 (if measured) and remain stable for 6-hours.
Exclusion criteria
Exclusion criteria: 1. Patient with >= Stage 4 chronic kidney disease (defined by an estimated glomerular filtration rate 2. Patient requiring renal replacement therapy (RRT) at admission/prior to enrollment. 3. Patient with known or suspected obstructive etiology for AKI. 4. Patients with severe acute malnutrion as per World Health Organization (WHO) classification (presence of bipedal edema of nutritional origin, weight-for-height or weight-for-length: Z-score 6months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the strength of agreement between the measured GFR by DTPA renal scan and estimated GFR by modified Schwartz formula in critically ill children at admission in PICU.Timepoint: Within 24 hours (during PICU stay). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To study the incidence of AKI in critically ill children at admission and during the PICU stays using p-RIFLE criteria.Timepoint: At 28 days (PICU stay);2. To study the time taken to achieve the renal recovery in the patients having AKI.Timepoint: At 28 days (PICU stay);3. To study the 28-days mortality rates in the patients having AKI and no AKI.Timepoint: At 28 days (PICU stay);4. To find out the difference, if any, in measured and estimated GFR in patients with and without AKI.Timepoint: At 28 days (PICU stay) | — |
Countries
India
Contacts
Public ContactDr R Ramesh Kumar
JIPMER
Outcome results
None listed