Health Condition 1: null- Pregnant patients for cesarean section under subarachnoid block
Conditions
Interventions
Intervention1: Crystalloid co-loading and normal saline: normal saline given 5 minutes before spinal anesthesia
Control Intervention1: colloid co-loading and Ondansetron: Ondansetron 4 mg given intra
Sponsors
MS UCMS and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Full term pregnant patients belonging to ASA Grade I undergoing cesarean section under subarachnoid block, having systolic blood pressure (SBP) more than 120 mm of Hg and with height of >140 cm and
Exclusion criteria
Exclusion criteria: Patients with history of Hypersensitivity to ondansetron, local anesthetic agents or colloids, Hypertensive disorders of pregnancy like pre-eclampsia, eclampsia, Cardiovascular diseases like MS, MR, AS; ischemic heart disease, hypertension of any cause will be excluded. Patients taking anti-emetics like metoclopramide and having ante-partum hemmorhage, multiple gestation, hydramnios will not be included.Patients with endocrine, renal or hepatic diseases, with fetal distress and those who refused to participate will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of hypotension and bradycardia in three groupsTimepoint: Heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure and SpO2 were recorded Pre-operatively, before subarachnoid injection, After subarachnoid injection every 2 min for 20 min and then every 5 min till the end of surgery and every 30 min for 3 hrs postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ephedrine required to maintain SBP, Atropine required to maintain HR,Frequency of nausea and vomiting and Neonatal APGAR score Timepoint: Ephedrine when SBP less than 100 mm of Hg, Atropine when HR less than 60 bpm, nausea and vomiting perioperatively and neonatal APGAR at 1,3,5 and 10 min. | — |
Countries
India
Contacts
Public ContactDr Nidhi Jain
UCMS and GTB hospital
Outcome results
None listed