Health Condition 1: null- pregnant women aged 18 to 45 years with previous one caesarean section admitted for second trimester termination.
Conditions
Interventions
Intervention1: Extra-amniotic saline instillation: 150 ml of 0.9% saline will be instilled extra-amniotically through Foleys catheter over 10 minutes
Control Intervention1: Oral Mifepristone followed
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Pregnant women 1)16 to 27+6 weeks of gestation 2)previous one caesarean section 3)admitted for termination of pregnancy-missed abortion, congenital anomalies, intra-uterine death, medical reasons
Exclusion criteria
Exclusion criteria: 1)known allergy to Misoprostol 2)recent history of asthma 3)previous rupture uterus 4)placenta covering os 5)pre-viable premature rupture of membranes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) To compare the efficacy and safety of extra-amniotic saline instillation versus combination of oral mifepristone and vaginal misoprostol for second trimester pregnancy termination in women with previous one caesarean section.Timepoint: Duration in hours. Induction to abortion interval is noted in both groups and compared. | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the efficacy and safety of combination of oral mifepristone with vaginal misoprostol for second trimester pregnancy termination in women with previous one caesarean sectionTimepoint: Duration in hours. Induction to abortion interval is noted.;To study the efficacy and safety of extra-amniotic saline instillation for second trimester pregnancy termination in women with previous one caesarean sectionTimepoint: Duration in hours. Induction to abortion interval is noted. | — |
Countries
India
Contacts
Public ContactDr Kuttuboina Madhuri
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed