Mini fluid challenge (MFC) , administering 100 ml of fluid over 1 minute and end expiratory occlusion test (EEOT) (stopping respiration in the expiratory phase by using expiratory pause button in the ventilator)for Predicting which patients with acute circulatory failure will respond to fluid

End expiratory occlusion test and Mini fluid challenge for predicting fluid responsiveness in Acute circulatory failure

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/09/009936

Enrollment

100

Registered

2017-09-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ACUTE CIRCULATORY FAILURE

Interventions

Intervention1: End expiratory occlusion teat (EEOT) and Mini fluid challenge (MFC): EEOT is performed by expiratory pause button of ventilator for 10 sec . MFC is performed by infusing 100 ml of NS in

Eligibility

Inclusion criteria

Inclusion criteria: •Systolic blood pressure less than 90 mm Hg. •Need of vasopressors to maintain systolic blood pressure > 90 mm Hg. •Urine output less than 0.5ml/kg/hr for 2 hours •Heart rate > 100 /min

Exclusion criteria

Exclusion criteria: 1)Patients not in sinus rhythm 2)Patients in whom echocardiography could not be performed (obesity, poor echo window) 3)Intra-abdominal hypertension 4)Contraindications to PLR test •Brain stroke or raised intracranial hypertension •Deep vein thrombosis •Lower limb or pelvis fracture •Inspiratory effort during EEOT

Design outcomes

Primary

Measure	Time frame
To find the correlation of End expiratory occulsion test (EEOT) and mini fluid challenge(MFC) induced rise in Aortic velocity time integral in predicting fluid responsiveness in acute circulatory failure in comparison to passive leg-raising test(PLR).Timepoint: Immediately after performing EEOT , MFC AND PLR Left ventricular outflow tract VTI will be measured.	—

Secondary

Measure	Time frame
To determine sensitivity, specificity and area under ROC curve of LVOT VTI after EEOT and mini fluid challenge to predict fluid responsiveness.Timepoint: NA	—

Countries

India

Contacts

Public ContactDR Dilip Shende

AIIMS

dr.velsri86@gmail.com9968859560

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026