Health Condition 1: null- Alcohol Withdrawal Or Intoxication
Conditions
Interventions
Intervention1: Memantine: non- competitive glutamatergic antagonist acting on NMDA receptors. 10mg tablet, given orally, twice daily for 14 days.
Control Intervention1: placebo: Placebo tablet given t
Sponsors
Dhruv Gupta
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosis of mental and behavioral disorders due to use of alcohol dependence syndrome- withdrawal state â?? F10.3 (ICD 10 criteria) Mild- to- moderate rating on CIWA- AR scale (10 or more); including intoxication Availability of a family member Willingness to give written informed consent as an in- patient
Exclusion criteria
Exclusion criteria: Any co- morbid psychiatric disorder except depression Significant neurological illness Any severe medical illness, or medical illness requiring emergency management Head injury Mental retardation Any other substance use or dependence in the past except nicotine and caffeine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| % Clinical Institute Withdrawal Scale (CIWA-Ar) scores more than 10, % Penn Alcohol Craving Scale (PACS) scores- within and between two groupsTimepoint: CIWA-Ar on day 1,3,7,14. PACS on day 1,7,14 | — |
Secondary
| Measure | Time frame |
|---|---|
| % Montgomery Asberg Depression Rating Scale (MARDS), % Clinical Global Impression scale (CGI)Timepoint: MADRS on day 1,14. CGI on day 1,14 | — |
Countries
India
Contacts
Public ContactDr Sumit Khattri
Shri Guru Ram Rai Institute Of Medical and Health Sciences
Outcome results
None listed