Whether administration of pre-medication solution before gastroscopy will diagnose the lesions better in food pipe, stomach and also help to reduce the total duration of that procedure ?

Efficacy of Simethicone alone Vs Simethicone and N-Acetyl Cysteine as premedication prior to Upper GI endoscopy â?? A Double blinded Randomized Placebo Controlled Trial in a tertiary care hospital

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/09/009913

Enrollment

768

Registered

2017-09-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- All patients who come for Upper GI endoscopy except with Clinical gastric outlet obstruction

Interventions

Intervention1: Simethicone: It is an anti-foaming agent which helps to remove foam and bubbles in upper gastrointestinal tract Intervention2: N-Acetyl Cysteine: It is a mucolytic agent which helps in

Eligibility

Inclusion criteria

Inclusion criteria: All patients undergoing diagnostic Gastroscopy (Age > 18 years)

Exclusion criteria

Exclusion criteria: Patients with clinical partial or complete gastric outlet obstruction, food debris, blood, or thick bile juice retained in the stomach, Pregnancy, having phenylketonuria or were suspected to have hypersensitivity to the trial medications

Design outcomes

Primary

Measure	Time frame
To detect the efficacy of Simethicone with N-Acetyl Cystiene combination as premedication for bowel preparation before Upper GI endoscopyTimepoint: END OF THE STUDY	—

Secondary

Measure	Time frame
i. To find the effectiveness of Simethicone with N-Acetyl Cystiene combination for better mucosal visibility using Total Mucosal Visibility Score (TMVS) ii. To estimate the total duration of the procedure time for each patient in various arms of the study groupsTimepoint: END OF THE STUDY	—

Countries

India

Contacts

Public ContactDr K Veeraraghavan

Pondicherry Institute of Medical Sciences

sangeetharaghavan2011@gmail.com9487831329

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026