A clinical trial to study the effect of dexmedetomidine to attenuate pressor response during intubation.

COMPARATIVE EVALUATION OF PROPOFOL AND PROPOFOL WITH DEXMEDETOMIDINE FOR ATTENUATION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND INTUBATION.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/09/009876

Enrollment

Registered

2017-09-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R932- Abnormal findings on diagnostic imaging of liver and biliary tract Health Condition 2: 4- Measurement and Monitoring

Interventions

Intervention1: dexmedetomidine and propofol: dexmedetomidine 1mcg/kg body wt in 100ml normal saline infused in 15 mins before induction and induction with propofol 2mg/kg body wt. Control Intervention

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II scheduled for elective surgical procedures under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patients with anticipated difficult airway management ,hiatus hernia, GERD, BMI >30, patients on antihypertensive drugs, patients on sedatives, hypnotics , and antidepressants, H/o cardiovascular, respiratory, hepatic , renal diseases, patients with ASA grades III & above , endocrine disease and malnourished will be excluded from study.

Design outcomes

Primary

Measure	Time frame
changes observed in vital parameters.Timepoint: up to ten minutes.	—

Secondary

Measure	Time frame
side effectsTimepoint: during whole surgical time period	—

Countries

India

Contacts

Public ContactAshutosh kumar singh

Nalanda Medical College and Hospital , Patna

vksinha04@gmail.com9334338755

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026