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This is a randomized control trial in the setup of living donor liver transplant. Here we are assessing the role of synbiotic agents (pre and probiotics) in reducing infectious complications in the immediate post-operative period after liver transplant.

A Prospective Randomised controlled trial analyzing role of peri-operative synbiotic treament to prevent infectious complications in patients undergoing elective living donor liver transplant.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/09/009869
Enrollment
60
Registered
2017-09-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing living donor liver transplant for CLD

Interventions

Intervention1: Study group: Patients who are administered trial drug (synbiotic agent). The trial drug is a synbiotic (probiotic + prebiotic) drug, by the name Prowel. It contains probiotics (Lactobac

Sponsors

Amrita Institute of Medical Sciences Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients between 18 and 70 yrs old. 2. Patients who are recipient of primary liver allografts from a living donor.

Exclusion criteria

Exclusion criteria: 1. Deceased donor liver transplant recepients 2.Multiorgan transplants 3.Culture proven pre-operative infection in recepient. 4.Intolerance to study medications.

Design outcomes

Primary

MeasureTime frame
To assess the effect of synbiotics on infection rate.Timepoint: 14 days post-operatively.—

Secondary

MeasureTime frame
1 Hospital & ICU length of stay 2 Antibiotics duration 3 30-day mortality 4 Acute graft rejection Timepoint: 14 days post-operatively.—

Countries

India

Contacts

Public Contactshweta mallick

Amrita Institute of Medical Sciences and Research Centre

sudhisalini@icloud.com9535066320

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 12, 2026