Comparison of the effects of Pregabalin, Dexmedetomidine, and their combination on the haemodynamic response and anaesthetic requirements

Comparative Evaluation Of The Effects Of Premedication With Pregabalin, Dexmedetomidine, and Their Combination On the Haemodynamic Response and Anaesthetic Requirements in patients undergoing Laparoscopic Cholecystectomy- A Randomised Double Blind Prospective Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/09/009862

Enrollment

Registered

2017-09-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA Grade 1 and 2

Interventions

Intervention1: Combination group will receive a combination of oral pregabalin 75mg one hour before induction, and a bolus intravenous dose of dexmedetomidine @0.5Âµg/kg(prepared in 100ml 0.9%normal s

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled to undergo elective laparoscopic cholecystectomy. ASA grades 1 and 2. Adult patients 18-65 years of age of either sex.

Exclusion criteria

Exclusion criteria: 1) patients with hypertension,morbid obesity, and cardiac, renal, hepatic, endocrine or pulmonary dysfunction 2) ASA grades 3 and 4

Design outcomes

Primary

Measure	Time frame
pulse,blood pressure,oxygen saturation,end tidal carbon dioxide, isoflurane concentration,fentanyl requirement, propofol requirement, ramsay sedation score, Visual Analogue ScaleTimepoint: baseline, 10, 20,30,40,45,50,55,60 minutes after premedication before induction, after 1,2,3 minutes of induction, after 1,3,5,10,15,30,45,60,75 minutes of intubation, before, after and end of pneumoperitoneum 15 minutes, 1 hour, 2 hours after extubation	—

Measure

Time frame

pulse,blood pressure,oxygen saturation,end tidal carbon dioxide, isoflurane concentration,fentanyl requirement, propofol requirement, ramsay sedation score, Visual Analogue ScaleTimepoint: baseline, 10, 20,30,40,45,50,55,60 minutes after premedication before induction, after 1,2,3 minutes of induction, after 1,3,5,10,15,30,45,60,75 minutes of intubation, before, after and end of pneumoperitoneum 15 minutes, 1 hour, 2 hours after extubation

—

Secondary

Measure	Time frame
time taken for patient to respond after reversal, time taken for extubation after reversalTimepoint: 15 minutes, 60 minutes, and 120 minutes postoperatively	—

Countries

India

Contacts

Public ContactNaveen K V

VMMC AND SAFDARJUNG HOSPITAL

drvandanatalwar@gmail.com9811352251

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026