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Efficacy of timolol in arresting progression in Keratoconus

Efficacy of topical ocular hypotensive agents in arresting progression of Keratoconus.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/09/009859
Enrollment
120
Registered
2017-09-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Keratoconus

Interventions

Intervention1: Timolol: Timolol is a Ã?-adrenergic blocking agent, successfully used for treating glaucoma. It is available both as an ophthalmic solution (0.25% or 0.5%) typically administered twice

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients between 15 to 30 years of age with a definitive diagnosis of keratoconus as in accordance with guidelines of Collaborative Longitudinal Evaluation of Keratoconus Group

Exclusion criteria

Exclusion criteria: Patients with associated ocular surface disease Systemic disorders like bronchial asthma cardiovascular disorders Pre existing glaucoma or use of antiglaucoma drugs H/o prior treatment with collagen cross linking H/o prior corneal hydrops History of use of contact lens in the last 3 weeks Pregnancy or lactation during the period of the study

Design outcomes

Primary

MeasureTime frame
Corneal tomographyTimepoint: Baseline (Day 0), Month 3, and Month 6.

Secondary

MeasureTime frame
Best spectacle-corrected Visual Acuity (BSCVA)Timepoint: Baseline (Day 0), Month 3, and Month 6.;Fundus and optic nerve head evaluationTimepoint: Baseline (Day 0), Month 3, and Month 6.;Intraocular pressureTimepoint: Baseline (Day 0), Month 3, and Month 6.;Manifest refractionTimepoint: Baseline (Day 0), Month 3, and Month 6.;Slit lamp biomicroscopyTimepoint: Baseline (Day 0), Month 3, and Month 6.;Uncorrected Visual Acuity (UCVA)Timepoint: Baseline (Day 0), Month 3, and Month 6.

Countries

India

Contacts

Public ContactDr Pravin V Krishna

LV Prasad Eye InstituteÂ

pravin@lvpei.org04030612345

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026