Health Condition 1: F31- Bipolar disorder Health Condition 2: null- Patients with Pediatric onset Bipolar disorder and controls.
Conditions
Interventions
Intervention1: Nil: Patients started on Lithium as part of treatment as usual will be recruited.
Single arm. Based on response status at the end of 2 years, they will be grouped as responders and non-
Sponsors
SERB Department of Science and Technology Government of India
Eligibility
Inclusion criteria
Inclusion criteria: Retrospective: 1) Patients with the diagnosis of bipolar disorder as per DSM 5 diagnostic criteria of South Indian origin. 2) Age at onset of first episode before 18 years. 3) Patients who are on regular treatment with Lithium. 4) On follow up for a minimum of 2 years. Prospective 1) Patients with the diagnosis of bipolar disorder as per DSM 5 diagnostic criteria of South Indian origin. 2) Age at onset of first episode before 18 years. 3) Patients who are started on Lithium as part of treatment as usual. 4) Who are willing for 6 monthly follow up for a minimum of 2 years after stabilization of treatment. Controls: Unrelated healthy controls of either gender of South Indian origin above 18 years of age without family history of Bipolar disorder.
Exclusion criteria
Exclusion criteria: Retrospective: 1) Patients with comorbid Intellectual disability or Autism spectrum disorder 2) Patients with Organic Bipolar disorder Prospective: 1) Patients with comorbid Intellectual disability or Autism spectrum disorder. 2) Patients with Organic Bipolar disorder 3) Adult female patients who are planning for pregnancy, currently pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify genomic bio-markers associated with prophylactic response to lIthium to improve predictability of treatment response in paediatric onset Bipolar disorder.Timepoint: At the end of 2 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of adverse drug reactions in paediatric onset bipolar disorder.Timepoint: 6 monthly for the prospective sample. | — |
Countries
India
Contacts
Public ContactPreeti Kandasamy
JIPMER
Outcome results
None listed