Health Condition 1: null- Acute kidney injury patients requiring renal replacement therapy
Conditions
Interventions
Intervention1: Online intermittent hemodiafiltration: This is a type of dialysis machine which involves both convective and diffusive clearances.
Control Intervention1: Conventional intermittent hemod
Sponsors
PGIMER chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. AKI stage 3 of KDIGO classification or Acute on CKD patients fulfilling standard criteria for requirement of renal replacement therapy 2. Presence of SIRS, fulfilling at least 2 out of 4 criteria
Exclusion criteria
Exclusion criteria: 1. Patients with hypotension requiring more than single inotropes 2. CKD and post renal transplant patients already on some form of renal replacement therapy 3. Indication of dialysis, toxin or drug removal 4. AKI patients with suspected or confirmed Glomerulonephritis, vasculitis or obstructive AKI 5. Terminal illness with associated life expectancy less than 2 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To examine the feasibility of conducting a larger study that will determine whether convective clearance confers improved outcome as compare to diffusive clearance using intermittent modes of RRT 2. To compare outcome in terms of renal recovery in patients with AKI and SIRS, undergoing online hemodiafiltration vs conventional hemodialysisTimepoint: 1 month | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in body fluid levels as assessed by bioimpedance machineTimepoint: 7 days;Change in qSOFA scoreTimepoint: 7 days;Change in serum cytokine concentration (IL6)Timepoint: 7 days;Mortality benefit Timepoint: 1 month | — |
Countries
India
Contacts
Public ContactSaurabh nayak
PGIMER, Chandigarh
Outcome results
None listed