Health Condition 1: null- Oral Submucous Fibrosis
Conditions
Interventions
Intervention1: Group A : Tablet Curcumin & Piperine 300mg: 300 mg tablets were administered two times daily for 6 months.
Intervention2: Group B: Oral lycopene: Total dose of 16mg given twice daily fo
Sponsors
Maulana Azad Institute Of Dental Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Clinically and histopathologically proven cases of OSMF 1) Positive history of chewing areca nut or one of its commercial preparation, difficulty in swallowing and chewing, and burning sensation on eating spicy food. 2) Restricted mouth opening and changes in the oral mucous membrane including the presence of vertical fibrous bands , stiffness and blanching. 30 positive history of tobacco, smoking, betel quid and alcohol.
Exclusion criteria
Exclusion criteria: 1) Those who were not willing to participate. 2)Patients who were already undertaking some treatment for existing potentially malignant disorder. 3)Patients with severe systemic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of burning sensation score, mouth opening, tongue protrusion and cheek flexibility between groups and within groupsTimepoint: At the time of first visit, every month till a period of 9 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reporting of malignant transformation over period of 9 months.Timepoint: Individuals were assessed every 4 weeks for 9 months. In case of any suspicion, biopsy was done. | — |
Countries
India
Contacts
Public ContactDr Sunita Gupta
Maulana Azad Institute of Dental Sciences
Outcome results
None listed