Health Condition 1: M459- Ankylosing spondylitis of unspecified sites in spine Health Condition 2: null- Patients with clinical symptoms and radiologically confirmed Ankylosing Spodylitis
Conditions
Interventions
Intervention1: Inj Infliximab with Rehabilitation programme: For Group A patients Screening for infection, serology, routine blood tests to be done and chest Skiagram to be obtained. Vaccination again
Sponsors
IPGMER SSKM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASAS criteria fulfilled AS patients. 2. Disease causing significant functional limitation. 3. Active disease for >= 4weeks 4. BASDAI >= 4 5. Failed adequate NSAIDs trial. 6. Patients giving consent for the study. 7. Patient mentally sound enough to communicate and participate in the study and can understand the parameters well.
Exclusion criteria
Exclusion criteria: 1. Active infection or septicaemia. 2. Documented Hypersensitivity. 3. Pregnancy. 4. Recent history of malignancy. 5. History of TB in recent past. 6. Congestive cardiac failure (NYHA Class III-IV). 7. Patients with Post myocardial infarction, Post stroke, Post mastectomy, prolonged immobilization. 8. The presence of an unstable medical condition or a known uncontrolled systemic disease, including cancer, diabetes, endocrine disease, major depression, schizophrenia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bath Ankylosing Spondylitis Functional Index (BASFI).Timepoint: At baseline, 2/6/12 weeks after initiation of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score (0 to 10) for back pain.Timepoint: At baseline, 2/6/12 weeks after initiation of treatment. | — |
Countries
India
Contacts
Public ContactAmbar Konar
IPGMER,SSKM Hospital
Outcome results
None listed