Health Condition 1: null- admitted patients requiring maintenance intravenous fluid.
Conditions
Interventions
Intervention1: isotonic fluid: isotonic (0.9% normal saline in 5% dextrose) maintainance fluid
Control Intervention1: hypotonic fluid: 0.45% normal saline in 5% dextrose intravenous fluid in normal ma
Sponsors
Chacha Nehru Bal Chikitsalaya
Eligibility
Inclusion criteria
Inclusion criteria: 1.All hospitalized children between 3 months to 5 years requiring intravenous maintenance fluid for at least 24 hours.
Exclusion criteria
Exclusion criteria: 1.Children with renal, hepatic or congestive heart failure 2.Children with hyponatremia (Na 145) at admission 3.Children with dehydration 4.Children requiring fluid boluses 5.Children who have received diuretics within last seven days 6.Children with severe malnutrition 7.Children with hemodynamic instability and requiring inotropes with or without mechanical ventilation 8.Children who had received intravenous fluid therapy in last 24 hours prior to admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hyponatremia (serum Na 135 meq/L) in children receiving isotonic fluid (0.9% normal saline with 5% dextrose) in comparison to children receiving hypotonic fluid (0.45% normal saline with 5% dextrose)Timepoint: 0 hour 12 hours 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of moderate (Na130 meq/L), severe (Na125 meq/L) and symptomatic hyponatremia (lethargy, altered sensorium or seizure) Change in serum sodium level from baseline Incidence of hypernatremia (serum Na 145 meq/L) Timepoint: 0 hour 12 hours 24 hours | — |
Countries
India
Contacts
Public ContactDr Kaustuv Mitra
Chacha Nehru Bal Chikitsalaya
Outcome results
None listed