A study to assess the effect Of the drug Tranexamic acid in reducing bloos loss during early excision of burn wound.

Effect Of Single Intravenous Tranexamic acid On Blood Loss During Tangential Excision Of Burn Wound.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/09/009629

Enrollment

Registered

2017-09-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Those Who Sustained Less Than 40% Burns And Hemodynamically Stable

Interventions

Intervention1: Tangential Excision Of Burn Wound: Early excision of the burn wound will be done by Tangentia excison. Control Intervention1: TRANEXAMIC ACID: During Tangential Excision Of Burn Wound s

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients presenting with thermal burns involving upto 30% TBSA with deep thermal component of atleast 5 % TBSA. 2. The thermal injury should be less than or equal to 6 days old 3. Age between 15-50 years

Exclusion criteria

Exclusion criteria: 1. Inhalational injury 2. Chemical & electrical burns 3. Burn injury >6 days old 4. Associated major injuries (head,chest,abdominal trauma) 5. Patient with history of bleeding disorders and on anticoagulation treatment 6. Non consenting patients 7. H/o Deep Vein Thrombosis,Myocardial infarction,CerebroVascular accident

Design outcomes

Primary

Measure	Time frame
To find the difference in average blood loss per cm2 area excised in patients who are given intravenous tranexamic acid during early tangential excision grafting of the burn wounds versus a control group To find the average amount of blood transfusion requirement per cm2 area excised and average fluid requirements during the intra operative period Timepoint: at the time of primary dressing,ie on post operative day 5	—

Measure

Time frame

To find the difference in average blood loss per cm2 area excised in patients who are given intravenous tranexamic acid during early tangential excision grafting of the burn wounds versus a control group To find the average amount of blood transfusion requirement per cm2 area excised and average fluid requirements during the intra operative period Timepoint: at the time of primary dressing,ie on post operative day 5

—

Secondary

Measure	Time frame
TO Find the average blood transfusion required per cm2 during tangential excision. Percentage of graft takeTimepoint: On post operative day 5	—

Countries

India

Contacts

Public ContactDR AJAI K S

PGIMER

parmodsadhu@gmail.com8146879988

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026