Health Condition 1: null- All the patients, aged 12 to 42 years of either sex, presenting with mild to moderate acne(â?¥ 2 but â?¤ 30 total lesions ).
Conditions
Interventions
Intervention1: Dapsone 5% gel: Patients were instructed to apply thin layer of dapsone 5% gel over the lesion twice daily for 12 weeks after rinsing the face and drying
Control Intervention1: Clindamy
Sponsors
Medical College Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: 1.Subjects of 12 to 40 years of age of either sex 2.Mild to moderate acne: >= 2 but 3.Lesions in the face which correspond to a baseline investigator global assessment (IGA) score of 2 or 3
Exclusion criteria
Exclusion criteria: 1.Age 40 2.Total lesion count 30, 3.Subjects regularly using any anti-acne medications in the last 30 days before study entry 4.Severe acne: Subjects with nodulo-cystic lesions, acne conglobata, acne fulminans 5.Pregnancy or intention of pregnancy and breastfeeding 6.Patients with G6PD deficiency 7.History of having taken any medication that could interact with dapsone (e.g. Trimetoprim-sulfametoxazol 8.Known hypersensitivity to the study medication 9.Patients not willing to comply with protocol requirements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A. To compare the effectiveness of topical dapsone 5% gel and clindamycin 1% gel in the treatment of acne vulgaris. 1.By Global acne assessment scale 2. By no. of acne lesion 3. By size of acne lesion B. To compare the safety of above mentioned regime 1. By laboratory method 2. By checklist adverse effectsTimepoint: A. Baseline, end of 4th, 8th and 12th week B. Baseline and post treatment value | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢To assess the improvement in quality of life with the two treatment regimeTimepoint: baseline and end of 12th week | — |
Countries
India
Contacts
Public ContactDr Amrita Sil
Paikpari Rural Hospital, Kolaghat
Outcome results
None listed