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use of morphine through two routes of epidural and intrathecal for pain management after lung surgery

Comparison of postoperative analgesic efficacy of intrathecal morphine versus epidural morphine in equivalent doses in patients undergoing thoracotomy for lung cancer surgeries- Prospective randomized study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/08/009560
Enrollment
40
Registered
2017-08-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients 18 years of age, of either sex undergoing elective thoracotomy for lung cancer under anaesthesia

Interventions

Intervention1: Group 2 (intrathecal group):: â?¢ In group 2 (intrathecal group): o 5 mcg/kg preservative free morphine in 1 ml normal saline will be given intrathecally via midline approach using 27

Sponsors

All India Institute of Medical Sciences New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: A total of forty patients >18 years of age, of either sex belonging to American Society of Anesthesiologists (ASA) physical status I-III undergoing elective thoracotomy for lung cancer under anaesthesia will be recruited in the study.

Exclusion criteria

Exclusion criteria: Patient with infection at the site of injection for central neuraxial block, coagulopathy, spine deformity, preexisting neurological deficit, patients with history of chronic pain, patients on opioids preoperatively, drug addicts, use of any analgesics during the last 48 hours before surgery, history of allergy to opioids or local anaesthetics, patients with previous thoracic surgeries, psychiatric disease, patients with liver disease, cardiac disease, renal failure and other contraindications of central neuraxial blockade will be excluded from the study. Patients requiring postoperative mechanical ventilation will also be excluded from the study.

Design outcomes

Primary

MeasureTime frame
1. Duration of analgesia: It will be defined as time from the administration of the epidural or intrathecal morphine as per group allocation till requirement of first rescue analgesia in the postoperative period (NRS3).Timepoint: After surgery, time at which patient will demand first rescue analgesics ie when NRS 3—

Secondary

MeasureTime frame
1. NRS at rest and during movement, coughing or deep breathing recorded every hourly for first 6 hours and then 4 hourly upto 24 hours. 2. Total consumption of morphine in 24 hours post operatively 3. Peak expiratory flow rate (PEFR), forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1), expressed as a percentage from the predicted values, will be measured pre-operatively and after 24 hours from recovery.Timepoint: POSTOPERATIVE PERIOD—

Countries

India

Contacts

Public ContactDR RAKESH GARG

AIIMS

drrgarg@hotmail.com9810394950

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026