Health Condition 1: O- Medical and Surgical Health Condition 2: null- Undergoing knee replacement surgery
Conditions
Interventions
Intervention1: Intravenous dexmedetomidine bolus and GA with propofol: GA with propofol and dexmedetomidine infusion
Control Intervention1: GA with propofol: GA with propofol and saline infusion
Contr
Sponsors
Department of Anaesthesia and Intensive care
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anaesthesiologists physical status I and II
Exclusion criteria
Exclusion criteria: Patients with significant cardiorespiratory, hepatic, renal, haematological and neurological dysfunction Patients on beta blockers, anticonvulsants, or any other centrally acting medications Anticipated difficult airway Pregnancy and lactation Patient allergic to the study drug Alcohol or substance abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| malondialdehyde levelsTimepoint: baseline 1 minute pior to tourniquet deflation 5 minute and 30 minutes after tourniquet deflation | — |
Secondary
| Measure | Time frame |
|---|---|
| Total anti oxidant status Arterial blood gas analysis Total tramadol consumption Sevoflurane consumption HaemodynamicsTimepoint: baseline 1 minute pior to tourniquet deflation 5 minute and 30 minutes after tourniquet deflation | — |
Countries
India
Contacts
Public ContactVanita Ahuja
Department of Anaesthesia and Intensive care
Outcome results
None listed