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Comparative study to evaluate the efficacy of dexmedetomidine via two routes i. e. intravenous and intrathecal in below knee surgeries under subarachnoid block

A comparative study of intravenous dexmedetomidine versus intrathecal dexmedetomidine as an adjuvant to heavy bupivacaine in subarachnoid block for below knee orthopedic surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/08/009546
Enrollment
90
Registered
2017-08-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients undergoing below knee orthopedic surgery

Interventions

Intervention1: GroupI: Patients will receive intrathecal 0.5% heavy bupivacaine 12.5mg (2.5ml) with 0.1 ml of normal saline and 0.5µg/kg of dexmedetomidine in100 ml 0.9% normal saline intravenous o

Sponsors

Dr Rajendra Prasad Government Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical class I- II BMI 18.5 Patient undergoing below knee orthopaedic surgeries under subarachnoid block

Exclusion criteria

Exclusion criteria: Patients refusal for participation in the study. Uncontrolled and labile hypertension. Allergic to study drugs. Absolute contraindication for spinal anesthesia. Patients using alpha2- adrenergic receptors antagonists. Patients noted to have dysrhythmias on the electrocardiogram.

Design outcomes

Primary

MeasureTime frame
Duration of postoperative analgesia and demand for rescue analgesia.Timepoint: Time of subarachnoid block and demand for rescue analgesia over a period of 24 hours in post operative period—

Secondary

MeasureTime frame
Haemodynamic stability. Onset and duration of sensory and motor block. Sedation.Timepoint: Haemodynamic stability in the intraoperative period for duration of surgery. duration of sensory and motor block asessed from the time of block till full recovery over period of 24 hours.—

Countries

India

Contacts

Public ContactDr Shelly Rana

Dr. R. P. G. M. C. Tanda , HPU

shelkbj@yahoo.com9418113786

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026