Health Condition 1: null- Schizophrenia Health Condition 2: F20- Schizophrenia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Schizophrenia Subject 1)ICD 10diagnosisof schizophrenia 2) capacity to provide informed consent 3)no other current comorbid axis I diagnosis (except nicotine abuse/dependence) and no general impaired intellectual functioning Healthy volunteers:â??1) Males and females between 18 and 45 years 2)Capacity to provide informed consent 3) absence of past or present psychiatric illnesses including substance abuse 4) no general impaired intellectual functioning
Exclusion criteria
Exclusion criteria: Exclusion criteria for both Patients and controls 1)Other current comorbid axis I diagnosis (except nicotine abuse/dependence) and general impaired intellectual functioning 2) History of alcohol or substance abuse or dependence in the last 12 months (with the exception of nicotine) 3)Past history of head injury resulting in loss of consciousness or neurosurgery 4)Concomitant severe medical conditions 5)Change in dose of antipsychotic medication or Electroconvulsive therapy in the past 6weeks 6)Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in Negative symptoms of schizophreniaTimepoint: 6 weeks of intervention 12 weeks of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in positive symptoms of schizophrenia Improvement in cognitive functions Changes in brain activation measured using fMRITimepoint: 6 weeks and 12 weeks of intervention (for positive symptoms and cognitive functions) 12 weeks of intervention for fMRI | — |
Countries
India
Contacts
National Institute of Mental health and neurosciences (NIMHANS)