Health Condition 1: null- planned for hysterectomy due to menorrhagia
Conditions
Interventions
Intervention1: misoprostol tablet: misoprostol vaginal tablet to be given half hour before hysterectomy
Control Intervention1: placebo tablets: placebo tablets to be given vaginally half hour before h
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: Symptomatic women undergoing total abdominal hysterectomy for various benign gynaecological diseases like 1) Fibroid uterus 2) Adebomyotic uterus 3) AUB not responding to medical management size >10 cms
Exclusion criteria
Exclusion criteria: 1. Hysterectomy to be performed for malignant diseases 2. Any contraindication to misoprostol (mitral stenosis, glaucoma, sickle cell anemia, diastolic blood pressure >100 mm Hg , severe asthma or known allergy to prostaglandins.) 3. Pelvic/ovarian endometriosis , associated PID , where dense pelvic adhesions are anticipated 4. History of active medical disease 5. History of myomectomy 6. Women who had pre-operative mifepristone or gonadotrophin releasing hormone analogues treatment 7. Women with mental impairment or incompetent in giving consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure : Intra-operative blood loss (in ml)Timepoint: Primary outcome measure : Intra-operative blood loss (in ml) Secondary outcome measures : 1) Requirement for post operative blood transfusion 2) Requirement for injectable iron 3) Change in hemoglobin level after operation 4) Incidence of side effects (drug , wound, pelvic collection) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures : 1) Requirement for post operative blood transfusion 2) Requirement for injectable iron 3) Change in hemoglobin level after operation 4) Incidence of side effects (drug , wound, pelvic collection) Timepoint: one week after operation | — |
Countries
India
Contacts
Public ContactMonika Anant
All India Institute of Medical Sciences Patna
Outcome results
None listed