Training to improve glucose control and cardiac fitness for patients with Type 2 Diabetes

Aerobic Training and its effects on Oxygen Kinetics and Oxidative Stress in Type 2 Diabetes Mellitus: A Dose-Response Study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/08/009459

Enrollment

Registered

2017-08-23

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Type 2 Diabetes Mellitus

Interventions

Intervention1: low volume

moderate intensity training: Treadmill walking: 3 sessions per week

each 30 min duration

moderate intensity (60% HRR) Intervention2: low volume

high intensity training: Treadmill walking: 3 sessions per week

vigorous intensity (80% HRR) Intervention3: High volume

moderate intensity training: Treadmill walking: 5 sessions per week

moderate intensity (60% HRR) Control Intervention1: Control Group: No supervised training

Eligibility

Inclusion criteria

Inclusion criteria: 1. Sedentary defined as not exercising more than 20 minutes on 3 or more days a week 2. Diabetes diagnosis > 1 year. 3. Already receiving oral anti-diabetic medications but have HbA1c levels 6.5-10% 4. Able to walk continuously for at least 20 min and climb one flight of stairs unaided without stopping

Exclusion criteria

Exclusion criteria: 1. BMI > 43kg/m2 2. Subjects on exogenous insulin 3. Retinopathy, nephropathy and neuropathy 4. Inflammatory and other conditions potentially associated with altered cytokine regulation 5. Autoimmune diseases 6. Hypothyroidism 7. Osteoporosis 8. Liver impairment 9. Renal insufficiency (creatinine levels > 2.0 mg/dl) 10. Diagnosed cardiovascular disease 11. Recent onset of cardiac-origin symptoms 12. Been prescribed a very low caloric diet (less than 1000 kcal/day) or drugs for the treatment of obesity 13. Orthopaedic problems limiting physical activity 14. Those already doing intensive physical activity > 2 h/week.

Design outcomes

Primary

Measure	Time frame
Vo2 max Oxygen Uptake Kinetics Heart Rate Recovery HbA1c Blood glucose Antioxidant enzymes (GPX, SOD, CAT) Timepoint: Baseline (0 week) 12 weeks	—

Secondary

Measure	Time frame
BMI Skin fold measurement Waist circumference Waist- Hip ratio BP Lipid profile (Total cholesterol, HDL, LDL)Timepoint: Baseline (0 week) 12 weeks	—

Countries

India

Contacts

Public ContactShalini

Jamia Millia Islamia

shaliniverma3001@gmail.com91-8860880605

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026