Health Condition 1: null- patients planned for Total knee replacement surgeries in oncology
Conditions
Interventions
Intervention1: KETAMINE: A NMDA receptor antagonist with a role in intraoperative analgesia
Control Intervention1: Saline: As per computer generated chart half of patients will get saline infusion. Th
Sponsors
Tata Memorial Centre Mumbai
Eligibility
Inclusion criteria
Inclusion criteria: All ASA I and ASA II patients posted for total knee replacement procedure above 13 yrs of age.
Exclusion criteria
Exclusion criteria: Patients not willing to be the part of study. With reconstructive surgery with major plastic flaps On preoperative opioid/drug abuse or on chronic pain medications. Pre-operative pathological fracture or muscle weakness of affected limb leading to limitation to mobility. Pregnant patients Patients in whom ketamine is to be avoided: Raised intracranial pressure, glaucoma medications Raised intraocular pressure History of vertigo, auditory/visual hallucinations On antipsychotic medications Intra-operative common peroneal nerve damage (post-operative exclusion) Post â??operative ventilation or hemodynamic instability preventing mobilization for more than 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare functional recovery using TUG test at end of 72 hours Timepoint: 72 hours in the post-operative period | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare opioid requirement . pain scores maximum flexion and extension achieved captured using goniometry. satisfaction with pain management using 5 point Likert- type scale from 1 (not at all satisfied) to 5 (extremely satisfied) at 72 hours. adverse effects using vomiting score, Ramsey sedation score and dysphoric experiences functional recovery at first follow-up using oxford knee score. Timepoint: 72 hours | — |
Countries
India
Contacts
Public ContactDr Susan Paulin
Tata Memorial Centre
Outcome results
None listed