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COMPARISON OF TWO DOSES OF DRUG (ANTIBIOTIC) IN SPINE SURGERY PATIENTS

SINGLE DOSE VS 24 hrs MULTIPLE DOSE ANTIBIOTIC PROPHYLAXIS IN ORTHOPAEDIC SPINE SURGERY PATIENTS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/08/009434
Enrollment
50
Registered
2017-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Spine surgery patients Health Condition 2: G55- Nerve root and plexus compressionsin diseases classified elsewhere

Interventions

Intervention1: inj cefazolin 1gm: 1 gm single pre op dose IV 30 min before skin incision Control Intervention1: inj cefazolin: 1 gm IV pre op 30 min before skin incision followed by 2 doses of 1 gm IV

Sponsors

Mahatma Gandhi Medical college Research Institute SriBalajiVidhyapeeth university
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 All the patients who will undergo orthopaedic spine(discectomy orlaminectomy) surgery will be included irrespective of age and gender

Exclusion criteria

Exclusion criteria: 1 Patients who had pre-existing infection. 2 Patients with hypersensitivity to the study drug 3 Patients who had taken antibiotic in the last two weeks prior to surgery 4 If surgery extends beyond 4 hrs or if intra op blood loss > 1500 ml patient will be excluded from study

Design outcomes

Primary

MeasureTime frame
surgical site infectionTimepoint: 2 5 and 12 th day post op—

Secondary

MeasureTime frame
Adverse drug reactionTimepoint: 2 5 and 12 th day post op—

Countries

India

Contacts

Public ContactDr Chandrasekaran M

Mahatma Gandhi Medical college Research Institute,Sri Balaji Vidhyapeeth University

chandruortho@gmail.com9443398534

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026