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Comparison of the effect of Dexmedetoidine (a drug which causes sedation lowers blood pressure and heart rate) on haemodynamic response (changes in blood pressure and heart rate) during Laparoscopic cholecystectomy (during laparoscopic cholecystectomy heart rate & blood pressure is increased)

Comparison of the effect of Dexmedetomidine loading and infusion dose on haemodynamic response during Laparoscopic cholecystectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/08/009417
Enrollment
60
Registered
2017-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- American society of anaesthesiologists physical class I & II

Interventions

Intervention1: Laparoscopic cholecystectomy and pneumoperitoneum: Laparoscopic cholecystectomy where pneumoperitoneum is created Control Intervention1: DEXMEDETOMIDINE Infusion: â?¢ Group A :Dexmedeto

Sponsors

AIIMS Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • ASA (American society of anaesthesiologists) I & II physical grading • Age between 18 to 60 years • Elective Laparoscopic Cholecystectomy

Exclusion criteria

Exclusion criteria: • Patients belonging to ASA(American society of anaesthesiologists) physical status III, IV and V • Patients with history of hypertension, diabetes • Patients with fixed cardiac output status like aortic stenosis, mitral stenosis • Patients with history of left ventricular failure, atrioventricular conduction block& severe cardiac disease • Patients with known history of bronchial asthma, chronic obstructive pulmonary disease • Patients with renal and hepatic derangements • Patients taking clonidine, beta blocking drugs, calcium channel blockers, MAO inhibitors • Elderly (age > 60 years) and age • History of allergy to α2 agonist

Design outcomes

Primary

MeasureTime frame
Effect of Dexmedetomidine loading and infusion dose on haemodynamic response during Laparoscopic cholecystectomy Any other adverse effects noted. Post operative Visual analogue score and Ramsay sedation score along with time of first rescue analgesic requirement notedTimepoint: â?¢ Before starting infusion â?¢ 15 minutes after starting the infusion â?¢ 1 minute after induction â?¢ 1 minute after intubation â?¢ 1 minute after pneumoperitoneum â?¢ 15 minutes after pneumoperitoneum â?¢ 30 minutes after pneumoperitoneum â?¢ 45 minutes after pneumoperitoneum â?¢ 1 minute after release of pneumoperitoneum â?¢ 1 minute after extubation—

Secondary

MeasureTime frame
â?¢ Degree of Sedation during immediate post-operative period â?¢ Analgesia during immediate post-operative period& time for first rescue analgesic requirement. Timepoint: 10 minutes after extubation—

Countries

India

Contacts

Public ContactDR UMESH KUMAR BHADANI

ALL INDIA INSTITUTE OF MEDICAL SCIENCES

umeshbhadani@gmail.com8969169123

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026