Health Condition 1: E785- Hyperlipidemia, unspecified Health Condition 2: null- Statin Naive patients
Conditions
Interventions
Intervention1: Atorvastatin: Atorvastatin 10/20mg given orally once a day for a duration of 3 months
Control Intervention1: NIL: NIL
Sponsors
Research Society Seth GSMC and KEM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Statin naïve patients aged between 18 -75 years of either gender, eligible for statin treatment as per the physicianâ??s diagnosis 2. Patient willing to give written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients having contraindication to statin like a)Chronic renal failure or serum creatinine > 1.7 times the upper limit b)Unexplained serum CK > 3 times the upper limit of normal Active hepatitis or cholestasis or ALT > 2 times the upper limit of normal. c)Subjects taking one of the following medications and unable to maintain a stable dose at least four weeks prior to the screening visit and for the duration of the study: tamoxifen, raloxifene, estrogen and or progestins, thiazide diuretics, isotretinoin, Ã?-blockers, thyroid hormones, androgens, fiber supplements, protease inhibitors. 2. Patients requiring any other lipid lowering agent other than statins. 3. Patients having co-morbidities like any liver disease. 4. Pregnant and lactating women. 5. Inability to comply with the treatment and study protocol as per the investigatorâ??s judgment. 6. History of alcohol and substance abuse in last four weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the effect of statins on PON-1 activity across different allelic variantsTimepoint: 4 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare serum lipid levels before and after statin treatment and its correlation with PON-1 activityTimepoint: 4 months | — |
Countries
India
Contacts
Public ContactCharuta Godbole
King Edward Memorial Hospital
Outcome results
None listed