Health Condition 1: null- age 18 to 75 yrs of both gender. Onset of stroke symptoms (ischemic) within 6 to 36 hours prior to beginning of treatment. NIHSS score more than 5. SBP more than 140 mmHg or DBP more than 90 mmHg
Conditions
Interventions
Intervention1: Nebivolol: Nebivolol 5mg once daily for ten days
Control Intervention1: Amlodipine: Amlodipine 5mg once daily for ten days
Sponsors
HINDU MISSION HOSPITAL
Deparment of clinical reserach
Eligibility
Inclusion criteria
Inclusion criteria: Onset of stroke symptoms ischemic within 6 to 36 hours prior to beginning of treatment. NIHSS score greater or equal to 5. Known case of hypertension or SBP more than 140 mmHg or DBP more than 90 mmHg.
Exclusion criteria
Exclusion criteria: Haemorrhagic Stroke, other Central Nervous System (CNS) diseases, including brain tumor, demyelinating diseases, inflammatory diseases, a history of craniotomy or severe brain injuries and idiopathic intracranial hypertension. Any known contra-indication to Nebivolol such as severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome, (unless a permanent pacemaker is in place), severe hepatic impairment (Child-Pugh >B). Acute or chronic renal failure. Pre-existing infectious disease requiring other antibiotic therapy. Pregnant Women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is to compare National Institute of Health Stroke Scale (NIHSS) score modified Barthel Index (mBI) and modified Rankin Scale (mRS) score at admission and on days 30 and 90 Timepoint: baseline 10 days 30 days and 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Events MonitoringTimepoint: baseline 10 days 30 days and 90 days | — |
Countries
India
Contacts
Public ContactDr Melvin George
Hindu Mission Hospital
Outcome results
None listed